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Many of the risk factors that have been described for anal cancer reflect infection with or persistence of anal hpv infection, including lifetime number of sexual partners, receptive anal intercourse and hiv infection (8, 20). Given the predominance of sccs among anal cancers, these risk factors likely reflect the causal association between hpv. anal cancer diagnoses and deaths are on the rise, according to a new study. Find out what cancer experts say about why rates are rising, and the anal cancer symptoms to watch for. Note a separate pdq summary on anal cancer treatment is also available. Who is at risk? Human papillomavirus (hpv) infection is the strongest risk factor for anal cancer and is accepted as a causal agent of squamous cell carcinoma of the anus and its precursor lesions. Behaviors or medical conditions that either indicate hpv infection or facilitate hpv transmission or persistence are. Oral contact with the anus can put both partners at risk for hepatitis, herpes, hpv, and other infections. But a diagnosis of anal cancer was definitely not on my radar. While anal cancer is fairly rare and much less common than colon or rectal cancer, the number of new cases in the united states has been on the rise for several decades. For 2017, the american cancer society estimates about 8,200 new cases and 1,100 deaths due to anal cancer. Again, it is the woman experiencing heterosexual anal intercourse who is at risk. D) the center for disease control and prevention (cdc) just released (august 2016) a new fact sheet on anal sex and hiv risk. The first statement on the page says, anal sex is the riskiest sexual behavior for getting and transmitting hiv for men and women. The most common types of cancer among men in the us are skin, prostate, lung, and colorectal cancer. Some younger men might be at risk of testicular cancer and hodgkin lymphoma. Some gay men, especially those who are hiv positive, might have a higher risk of anal cancer.